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Choosing between API 600 and API 602 gate valves is a critical decision in industrial piping design. While both standards are widely used for isolation service in oil and gas, petrochemical, power generation, and chemical processing applications, they are intended for different operating conditions and piping configurations. API 600 gate valves are typically cast steel valves designed for medium- and large-diameter pipelines, offering robust construction, high flow capacity, and excellent maintainability. API 602 gate valves, on the other hand, are forged steel valves primarily used in small-bore, high-pressure piping systems where compact design, mechanical strength, and pressure integrity are essential. This technical guide compares API 600 and API 602 gate valves in terms of construction, size range, pressure ratings, bonnet designs, applications, and selection criteria, helping engineers and procurement professionals choose the most suitable valve standard for their projects.